Our group investigates the functional mechanism of membrane-embedded heterooligomeric macromolecular machines in their native environments. We characterize the structural transitions, conformational equilibria, and the thermodynamic parameters to understand the mechanistic basis of their function. To achieve this goal, we employ a highly interdisciplinary approach involving recombinant membrane protein expression and purification, biochemical/biophysical characterization, and electron spin resonance spectroscopy (ESR) techniques combined with structural modeling. 


The group focuses on four main aspects:





  • Lipopolysaccharide (LPS) transport by the Lpt system


Our group is located at the Institute of Biophysics in the Department of Physics. We are associated with the Center for Biomolecular Magnetic Resonance (BMRZ) . Our research is funded by the Emmy Noether-Program of the Deutsche Forschungsgemeinschaft (DFG) and the Collaborative Research Center, CRC 807.



August 2020

  • Our latest work on the thermodynamics of the ABC exporter TmrAB is published in the Journal of Physical Chemistry Letters! https://doi.org/10.1021/acs.jpclett.0c01876

  • Welcome to Jingyi Liu! She starts with her Ph.D. in our group

June 2020

  • Welcome to Sarah Grudzinski! She starts the Master Internship in our group

May 2020

  • Welcome to Gabriel Tappermann! He starts the Master Thesis in our group

  • We are hiring! A new PhD position is open for a qualified person to join our young and dynamic group. Please check open positions for more details.

March 2020

  • Exciting time ahead! DFG approves one million euro funding for our group to procure a Q-Band Pulsed ESR Spectrometer!!

June 2019

  • Welcome to Marina Dajka! She starts her PhD in our group.

  • Welcome to Aathira Gopinath! She starts her PhD in our group.

May 2019

  • Welcome to Michael Rudolph! He starts his PhD in our group.

April 2019

Our collaborative work with the Geertsma and the Hummer group titled 'Structural basis for functional interactions in dimers of SLC26 transporters' is accepted for publication in Nature Communications!

Mar 2019

  • Welcome to Sophie Ketter! She starts her Bachelor Thesis in the group.

Feb 2019

  • Our manuscript titled 'In-situ observation of conformational dynamics and protein- ligand/substrate interaction in outer membrane proteins with DEER/PELDOR spectroscopy' is accepted for publication in Nature Protocols!

Dec 2018

Nov 2018

  • Our new group is all set to start from 1st Jan 2019. Plenty of lab and office space waiting!

Oct 2018

Sept 2018

  • Benesh receives the Young Investigator Award of the German Biophysical Society!

  • The DFG Senate approves our Emmy Noether Research Group! Exciting time ahead...


© 2020 by Benesh Joseph

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